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Neuron Glia Biol. 2007 Feb;3(1):63-74. doi: 10.1017/S1740925X07000646.

The scoop on the fly brain: glial engulfment functions in Drosophila.

Author information

  • 1University of Massachusetts Medical School, Department of Neurobiology 770P, 364 Plantation Street, Worcester, MA 01605, USA. mary.logan@umassmed.edu

Abstract

Glial cells provide support and protection for neurons in the embryonic and adult brain, mediated in part through the phagocytic activity of glia. Glial cells engulf apoptotic cells and pruned neurites from the developing nervous system, and also clear degenerating neuronal debris from the adult brain after neural trauma. Studies indicate that Drosophila melanogaster is an ideal model system to elucidate the mechanisms of engulfment by glia. The recent studies reviewed here show that many features of glial engulfment are conserved across species and argue that work in Drosophila will provide valuable cellular and molecular insight into glial engulfment activity in mammals.

KEYWORDS:

Drosophila glia; Phagocyte; phagocytosis

PMID:
18172512
[PubMed]
PMCID:
PMC2171361
Free PMC Article

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