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Genes Dev. 2008 Jan 1;22(1):8-13. doi: 10.1101/gad.1613108.

A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands.

Author information

  • 1Broad Institute of Massachussetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02141, USA. alex.stark@mit.edu

Abstract

MicroRNAs (miRNAs) are approximately 22-nucleotide RNAs that are processed from characteristic precursor hairpins and pair to sites in messages of protein-coding genes to direct post-transcriptional repression. Here, we report that the miRNA iab-4 locus in the Drosophila Hox cluster is transcribed convergently from both DNA strands, giving rise to two distinct functional miRNAs. Both sense and antisense miRNA products target neighboring Hox genes via highly conserved sites, leading to homeotic transformations when ectopically expressed. We also report sense/antisense miRNAs in mouse and find antisense transcripts close to many miRNAs in both flies and mammals, suggesting that additional sense/antisense pairs exist.

PMID:
18172160
[PubMed - indexed for MEDLINE]
PMCID:
PMC2151017
Free PMC Article

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