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1: Genome Biol. 2008 Jan 3;9:R2. [Epub ahead of print]Click here to read Click here to read Links

High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae.

Lee HG, Lee HS, Jeon SH, Chung TH, Lim YS, Huh WK.

School of Biological Sciences and Research Center for Functional Cellulomics, Institute of Microbiology, Seoul National University, Seoul 151-747, Republic of Korea. wkh@snu.ac.kr.

ABSTRACT: We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution.

PMID: 18171483 [PubMed - as supplied by publisher]

PMCID: PMC2395236