J Infect Dis. 2008 Jan 1;197(1):10-7.

Epidemiology and clinical significance of pneumocystis colonization.

Source

Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. morrisa@upmc.edu

Abstract

Pneumocystis pneumonia has long been recognized as a cause of morbidity and mortality in immunocompromised populations, particularly those with HIV infection. Pneumocystis colonization-that is, detection of the organism or its DNA, without signs or symptoms of pneumonia-has recently been described, and accumulating evidence suggests that it may be an important clinical phenomenon. Sensitive molecular techniques such as polymerase chain reaction are frequently used to identify Pneumocystis colonization. Low levels of Pneumocystis in the lungs may stimulate pulmonary inflammation and may play a role in the development of lung diseases such as chronic obstructive pulmonary disease. In this review, we discuss evidence for the occurrence of Pneumocystis colonization in animals as well as the epidemiology and risk factors for Pneumocystis colonization in various human populations. We also evaluate the clinical significance of Pneumocystis colonization and its relationship to lung disease.

PMID:: 18171279; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

[Current epidemiology of Pneumocystis jirovecii infections]. [Przegl Epidemiol. 2009]
[Current epidemiology of Pneumocystis jirovecii infections].
Gołab E. Przegl Epidemiol. 2009; 63(3):353-7.
Pneumocystis infection and the pathogenesis of chronic obstructive pulmonary disease. [Immunol Res. 2011]
Pneumocystis infection and the pathogenesis of chronic obstructive pulmonary disease.
Norris KA, Morris A. Immunol Res. 2011 Aug; 50(2-3):175-80.
Low prevalence of Pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia. [Diagn Microbiol Infect Dis. 2012]
Low prevalence of Pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia.
Taylor SM, Meshnick SR, Worodria W, Andama A, Davis JL, Cattamanchi A, den Boon S, Yoo SD, Goodman CD, Huang L, et al. Diagn Microbiol Infect Dis. 2012 Feb; 72(2):139-43. Epub 2011 Dec 5.
Review Immunopathogenesis of Pneumocystis carinii pneumonia. [Expert Rev Mol Med. 2005]
Review Immunopathogenesis of Pneumocystis carinii pneumonia.
Gigliotti F, Wright TW. Expert Rev Mol Med. 2005 Nov 14; 7(26):1-16. Epub 2005 Nov 14.
Review Pneumocystis jirovecii colonization in chronic pulmonary disease. [Parasite. 2011]
Review Pneumocystis jirovecii colonization in chronic pulmonary disease.
Gutiérrez S, Respaldiza N, Campano E, Martínez-Risquez MT, Calderón EJ, De La Horra C. Parasite. 2011 May; 18(2):121-6.

See reviews... See all...

Cited by 8 PubMed Central articles

Pneumocystis carinii infection causes lung lesions historically attributed to rat respiratory virus. [Comp Med. 2011]
Pneumocystis carinii infection causes lung lesions historically attributed to rat respiratory virus.
Livingston RS, Besch-Williford CL, Myles MH, Franklin CL, Crim MJ, Riley LK. Comp Med. 2011 Feb; 61(1):45-59.
Decreased serum antibody responses to recombinant pneumocystis antigens in HIV-infected and uninfected current smokers. [Clin Vaccine Immunol. 2011]
Decreased serum antibody responses to recombinant pneumocystis antigens in HIV-infected and uninfected current smokers.
Crothers K, Daly KR, Rimland D, Goetz MB, Gibert CL, Butt AA, Justice AC, Djawe K, Levin L, Walzer PD. Clin Vaccine Immunol. 2011 Mar; 18(3):380-6. Epub 2010 Dec 29.
Review Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumonia. [Crit Care. 2010]
Review Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumonia.
Christ-Crain M, Opal SM. Crit Care. 2010; 14(1):203. Epub 2010 Feb 8.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Epidemiology and clinical significance of pneumocystis colonization.
Epidemiology and clinical significance of pneumocystis colonization.
J Infect Dis. 2008 Jan 1 ;197(1):10-7.

PubMed
Powdered infant formula as a source of Salmonella infection in infants.
Powdered infant formula as a source of Salmonella infection in infants.
Clin Infect Dis. 2008 Jan 15 ;46(2):268-73.

PubMed
Activation of the coagulation cascade in patients with leptospirosis.
Activation of the coagulation cascade in patients with leptospirosis.
Clin Infect Dis. 2008 Jan 15 ;46(2):254-60.

PubMed
Voriconazole therapeutic drug monitoring in patients with invasive mycoses impro...
Voriconazole therapeutic drug monitoring in patients with invasive mycoses improves efficacy and safety outcomes.
Clin Infect Dis. 2008 Jan 15 ;46(2):201-11.

PubMed
Emergence of invasive pneumococcal disease caused by nonvaccine serotypes in the...
Emergence of invasive pneumococcal disease caused by nonvaccine serotypes in the era of 7-valent conjugate vaccine.
Clin Infect Dis. 2008 Jan 15 ;46(2):174-82.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Epidemiology and clinical significance of pneumocystis colonization.

Source

Abstract

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 8 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information