Comparison of the 24-hour intraocular pressure-lowering effects of latanoprost and dorzolamide/timolol fixed combination after 2 and 6 months of treatment

Ophthalmology. 2008 Jan;115(1):99-103. doi: 10.1016/j.ophtha.2007.03.007.

Abstract

Purpose: To evaluate the 24-hour intraocular pressure (IOP)-lowering effect of latanoprost and the dorzolamide/timolol fixed combination (DTFC) after 2 and 6 months of treatment.

Design: Randomized, prospective, crossover comparison.

Participants: Thirty-nine patients had primary open-angle glaucoma, and 14 patients had ocular hypertension.

Methods: After a 6-week washout period, patients were randomized to either 6 months of treatment with the DTFC twice daily or latanoprost every evening and then crossed over to the opposite treatment for an additional 6 months.

Main outcome measure: Mean 24-hour IOP after 2 and 6 months of treatment.

Results: Fifty-three patients had an average 24-hour baseline IOP of 25.2+/-2.3 mmHg. After 6 months of treatment, 24-hour IOPs were 18.1+/-1.9 mmHg for the DTFC and 18.3+/-1.9 mmHg for latanoprost. Compared with 2 months of therapy, at 6 months the DTFC showed no significant change in mean 24-hour IOP, whereas latanoprost demonstrated a reduction of 0.3 mmHg (P = 0.01). The DTFC had more burning (P<0.001) and bitter taste (P = 0.01), whereas the latanoprost had more hypertrichosis (P = 0.02).

Conclusions: After 6 months of therapy, the DTFC and latanoprost have clinically similar 24-hour IOP-lowering efficacies.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antihypertensive Agents / adverse effects
  • Antihypertensive Agents / therapeutic use*
  • Circadian Rhythm / drug effects*
  • Cross-Over Studies
  • Drug Combinations
  • Female
  • Glaucoma, Open-Angle / drug therapy*
  • Humans
  • Intraocular Pressure / drug effects*
  • Latanoprost
  • Male
  • Middle Aged
  • Ocular Hypertension / drug therapy
  • Prospective Studies
  • Prostaglandins F, Synthetic / adverse effects
  • Prostaglandins F, Synthetic / therapeutic use*
  • Sulfonamides / adverse effects
  • Sulfonamides / therapeutic use*
  • Therapeutic Equivalency
  • Thiophenes / adverse effects
  • Thiophenes / therapeutic use*
  • Time Factors
  • Timolol / adverse effects
  • Timolol / therapeutic use*
  • Tonometry, Ocular
  • Treatment Outcome

Substances

  • Antihypertensive Agents
  • Drug Combinations
  • Prostaglandins F, Synthetic
  • Sulfonamides
  • Thiophenes
  • dorzolamide-timolol combination
  • Latanoprost
  • Timolol