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Nat Methods. 2008 Jan;5(1):16-8. doi: 10.1038/nmeth1156. Epub 2007 Dec 19.

Next-generation sequencing transforms today's biology.

Author information

  • Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA. scs@bx.psu.edu

Abstract

A new generation of non-Sanger-based sequencing technologies has delivered on its promise of sequencing DNA at unprecedented speed, thereby enabling impressive scientific achievements and novel biological applications. However, before stepping into the limelight, next-generation sequencing had to overcome the inertia of a field that relied on Sanger-sequencing for 30 years.

PMID:
18165802
[PubMed - indexed for MEDLINE]
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