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1: J Nat Prod. 2008 Jan;71(1):102-5. Epub 2007 Dec 29.Click here to read Links

Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants.

Aponte JC, Vaisberg AJ, Rojas R, Caviedes L, Lewis WH, Lamas G, Sarasara C, Gilman RH, Hammond GB.

Department of Chemistry, University of Louisville, KY 40292, USA.

The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2',4'-dihydroxy-6'-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2',4'-dihydroxy-4,6'-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

PMID: 18163590 [PubMed - indexed for MEDLINE]

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