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Nucleic Acids Res. 2008 Jan;36(Database issue):D679-83. Epub 2007 Dec 26.

PepCyber:P~PEP: a database of human protein protein interactions mediated by phosphoprotein-binding domains.

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  • 1Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract

Phosphoprotein-binding domains (PPBDs) mediate many important cellular and molecular processes. Ten PPBDs have been known to exist in the human proteome, namely, 14-3-3, BRCT, C2, FHA, MH2, PBD, PTB, SH2, WD-40 and WW. PepCyber:P approximately PEP is a newly constructed database specialized in documenting human PPBD-containing proteins and PPBD-mediated interactions. Our motivation is to provide the research community with a rich information source emphasizing the reported, experimentally validated data for specific PPBD-PPEP interactions. This information is not only useful for designing, comparing and validating the relevant experiments, but it also serves as a knowledge-base for computationally constructing systems signaling pathways and networks. PepCyber:P approximately PEP is accessible through the URL, http://www.pepcyber.org/PPEP/. The current release of the database contains 7044 PPBD-mediated interactions involving 337 PPBD-containing proteins and 1123 substrate proteins.

PMID:
18160410
[PubMed - indexed for MEDLINE]
PMCID:
PMC2238930
Free PMC Article
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