RNA polymerase I: a multifunctional molecular mach...[Cell. 2007]

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1: Cell. 2007 Dec 28;131(7):1224-5. Links

Comment on:: Cell. 2007 Dec 28;131(7):1260-72.

RNA polymerase I: a multifunctional molecular machine.

Haag JR, Pikaard CS.

Department of Biology, Washington University, 1 Brookings Drive, St. Louis, MO, USA.

In this issue, Kuhn et al. (2007) report the complete structure of the 14-subunit yeast RNA polymerase (Pol) I enzyme at 12 A resolution using cryo-electron microscopy (cryo-EM). Their study reveals that three subunits of Pol I perform functions in transcription elongation that are outsourced to the transcription factors TFIIF and TFIIS in the analogous Pol II transcription system.

PMID: 18160031 [PubMed - indexed for MEDLINE]

Functional architecture of RNA polymerase I. [Cell. 2007]
TFIIS elongation factor and Mediator act in conjunction during transcription initiation in vivo. [Proc Natl Acad Sci U S A. 2007]
The FACT complex travels with elongating RNA polymerase II and is important for the fidelity of transcriptional initiation in vivo. [Mol Cell Biol. 2003]
RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing. [Proc Natl Acad Sci U S A. 2006]
The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes. [Proc Natl Acad Sci U S A. 2007]
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RNA polymerase I: a multifunctional molecular machine.

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