Eur J Clin Pharmacol. 1991;41(6):615-7.

Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers.

Bano G, Raina RK, Zutshi U, Bedi KL, Johri RK, Sharma SC.

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Department of Pharmacology and Therapeutics, Government Medical College, Jammu-Tawi, India.

Abstract

The effect of piperine on the bioavailability and pharmacokinetics of propranolol and theophylline has been examined in a crossover study. Six subjects in each group received a single oral dose of propranolol 40 mg or theophylline (150 mg) alone or in combination with piperine 20 mg daily for 7 days. An earlier tmax and a higher Cmax and AUC were observed in the subjects who received piperine and propranolol. It produced a higher Cmax, longer elimination half-life and a higher AUC with theophylline. In clinical practice, the enhanced systemic availability of oral propranolol and theophylline could be exploited to achieve better therapeutic control and improved patient compliance.

PMID:: 1815977; [PubMed - indexed for MEDLINE]

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