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J Allergy Clin Immunol. 2008 Feb;121(2):343-7. Epub 2007 Dec 26.

Specific oral tolerance induction in children with very severe cow's milk-induced reactions.

Author information

  • 1Pediatric Department, D.S.R.S., I.R.C.C.S. "Burlo Garofolo," University of Trieste, Trieste, Italy.

Abstract

BACKGROUND:

Some children allergic to cow's milk proteins (CMPs) experience exceptionally severe reactions after ingesting only trace amounts of antigen. Avoiding the food and carrying self-injectable epinephrine are the current strategies for their management.

OBJECTIVE:

The aim of this study was to evaluate the safety and efficacy of specific oral tolerance induction (SOTI) for children with severe CMP-induced systemic reactions.

METHODS:

Ninety-seven children aged 5 years or older with a history of severe allergic reactions and very high CMP-specific IgE levels were selected for a double-blind, placebo-controlled food challenge. Sixty had positive test results to very small amounts of milk and were randomly divided in 2 different groups. Thirty children (group A) immediately began SOTI, whereas the remaining 30 (group B) were kept on a milk-free diet and followed for 1 year.

RESULTS:

After 1 year, 11 (36%) of 30 children in group A had become completely tolerant, 16 (54%) could take limited amounts of milk (5-150 mL), and 3 (10%) were not able to complete the protocol because of persistent respiratory or abdominal complaints. In group B the result of the double-blind, placebo-controlled food challenge performed after a year was positive in all 30 cases (P < .001).

CONCLUSIONS:

In this study SOTI was effective in a significant percentage of cases.

Comment in

PMID:
18158176
[PubMed - indexed for MEDLINE]
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