Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Pediatr. 2008 Jan;152(1):50-4, 54.e1. Epub 2007 Oct 24.

Developmental changes in soluble CD40 ligand.

Author information

  • 1Department of Pediatrics, University of Rochester Medical Center, Rochester, New York 14642, USA.

Abstract

OBJECTIVES:

To determine if soluble CD40 ligand (sCD40L; formally CD154) levels vary with age and to identify age-dependent ranges in healthy pediatric and adult populations.

STUDY DESIGN:

sCD40L was measured in 25 neonates, 74 children (3 months-15 years of age) and 20 adults using an enzyme-linked immunosorbent assay. For age group comparisons, Mann-Whitney tests were performed. Correlation coefficients assessed relationships between plasma and serum sCD40L.

RESULTS:

Plasma sCD40L levels were higher in neonates than in all other age groups, (P <.001). All grouped pediatric plasma levels were significantly higher than in adults (P < .0001). There were no significant differences in plasma sCD40L between pediatric age groups. Serum levels were significantly higher in neonates than in any other age group (P < .0001). Pediatric and adult serum sCD40L levels were not significantly different.

CONCLUSIONS:

Plasma sCD40L levels are highest at birth and remain higher than those in adults throughout childhood. Reasons for such developmental changes remain to be investigated. Age-appropriate reference ranges should be used when sCD40L is being evaluated in pediatric disorders.

PMID:
18154898
[PubMed - indexed for MEDLINE]
PMCID:
PMC2572769
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk