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Oncology (Williston Park). 2007 Oct;21(11 Suppl 5):4-9.

Clinical presentation and pathophysiology of EGFRI dermatologic toxicities.

Author information

  • 1Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. edith.mitchell@jefferson.edu

Abstract

This review summarizes the pathophysiology and clinical presentation of the cutaneous toxicities associated with EGFR inhibition. Such effects include papulopustular reactions, xerosis, pruritus, fissures, nail changes, hair changes, telangiectasias, hyperpigmentation, and mucositis. Most management strategies for these toxicities have been based on anecdotal experience; clinical trials are needed to provide uniform characterization to allow for evidence-based treatment strategies.

PMID:
18154212
[PubMed - indexed for MEDLINE]
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