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Swedish Family Practice Residency, Swedish Hospital Medical Center, Seattle, WA 98104.
Post-transfusion purpura is a complication of blood product transfusion in which the recipient produces antiplatelet antibodies resulting in severe thrombocytopenia. The typical patient is a multiparous woman who develops sudden severe purpura 1 week after receiving a transfusion of packed red cells or whole blood. Post-transfusion purpura should, however, be considered in any patient with thrombocytopenia following infusion of a blood product. Untreated, the disease can be fatal or cause serious morbidity. Treatment options include plasmapheresis, intravenous immunoglobulin, and corticosteroids. Platelet transfusion is usually unsuccessful.
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