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    Cancer Immunol Immunother. 2008 May;57(5):745-52. Epub 2007 Dec 21.

    A HLA-Cw*0701 restricted Melan-A/MART1 epitope presented by melanoma tumor cells to CD8+ tumor infiltrating lymphocytes.

    Larrieu P, Renaud V, Godet Y, Jotereau F, Fonteneau JF.

    Source

    Institut de biologie, 9 quai moncousu, 44093, Nantes Cedex, France.

    Abstract

    Melan-A/MART1 is a melanocytic differentiation antigen recognized on melanoma tumor cells by CD8+ and CD4+ T cells. In this study, we describe a new epitope of this protein recognized in the context of HLA-Cw*0701 molecules by a CD8+ tumor infiltrating lymphocyte (TIL) clone. This CD8+ TIL clone specifically recognized and killed a fraction of melanoma cells lines expressing Melan-A/MART1 and HLA-Cw*0701. We further show that the Melan-A/MART1(51-61) peptide is the optimal peptide recognized by this clone. Together, these data significantly enlarge the fraction of melanoma patients susceptible to benefit from a Melan-A/MART1 vaccine approach.

    PMID:
    18097665
    [PubMed - indexed for MEDLINE]

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