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Nat Rev Immunol. 2008 Jan;8(1):22-33.

Germinal centres: role in B-cell physiology and malignancy.

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  • 1Institute for Cancer Genetics, Departments of Pathology and Genetics & Development, and Herbert Irving Comprehensive Cancer Center, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA.

Abstract

Over the past several years, studies on normal and malignant B cells have provided new insights into the unique physiology of the germinal centre (GC). In particular, advances in technology have allowed a more precise dissection of the phenotypes of GC B cells and the specific transcriptional programmes that are responsible for this phenotype. Furthermore, substantial progress has been made in the understanding of the mechanism controlling the exit of B cells from the GC and the decision to become a memory B cell or plasma cell. This Review focuses on these recent advances and discusses their implications for the pathogenesis of B-cell lymphomas.

PMID:
18097447
[PubMed - indexed for MEDLINE]
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