Gene prediction: compare and CONTRAST.

European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101SD, UK. flicek@ebi.ac.uk

CONTRAST, a new gene-prediction algorithm that uses sophisticated machine-learning techniques, has pushed de novo prediction accuracy to new heights, and has significantly closed the gap between de novo and evidence-based methods for human genome annotation.

PMID: 18096089 [PubMed - indexed for MEDLINE]

PMCID: PMC2246255