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Nanomedicine (Lond). 2007 Dec;2(6):789-803.

Characterization of nanoparticles for therapeutics.

Author information

  • 1SAIC-Frederick Inc., Nanotechnology Characterization Laboratory, Advanced Technology Program, NCI-Frederick, 1050 Boyles St., Bldg. 469, Frederick, MD 21702, USA.

Abstract

Nanotechnology offers many advantages to traditional drug design, delivery and medical diagnostics; however, nanomedicines present considerable challenges for preclinical development. Nanoparticle constructs intended for medical applications consist of a wide variety of materials, and their small size, unique physicochemical properties and biological activity often require modification of standard characterization techniques. A rational characterization strategy for nanomedicines includes physicochemical characterization, sterility and pyrogenicity assessment, biodistribution (absorption, distribution, metabolism and excretion [ADME]) and toxicity characterization, which includes both in vitro tests and in vivo animal studies. Here, we highlight progress for a few methods that are uniquely useful for nanoparticles or are indicative of their toxicity or efficacy.

PMID:
18095846
[PubMed - indexed for MEDLINE]
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