Department of Radiology, University of Washington, Box 359728, 325 Ninth Ave., Seattle, WA 98104, USA. tdub@u.washington.edu
OBJECTIVE: The objective of this article is to introduce the reader to the principles and applications of high-intensity focused ultrasound (HIFU). CONCLUSION: Although a great deal about HIFU physics is understood, its clinical applications are currently limited, and multiple trials are underway worldwide to determine its efficacy.