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Diagn Pathol. 2007 Dec 19;2:49.

Monomorphic post-transplant lymphoproliferative disorder of the tongue: case report and review of literature.

Author information

  • 1Department of Pathology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD, USA. luisgonzcuyar@gmail.com

Abstract

BACKGROUND:

Post-transplant lymphoproliferative disorder (PTLD) is a spectrum of hematological diseases arising in context of immunosuppression after organ transplantation. PTLD can involve any organ; however, it is extremely rare in oral cavity.

METHODS:

Using morphologic and immunophenotypic approaches we have studied a case of monomorphic PTLD of the tongue that developed in a patient following unilateral kidney and pancreas transplantation on immunosuppressive therapy. Additionally, cases of PTLD in the oral cavity were reviewed in the English literature.

RESULTS:

The neoplasm showed large cell morphology and B-cell phenotype. In situ hybridization for Epstein-Barr virus was positive. Complete remission was obtained after decreasing immunosuppressive therapy. The patient remained in remission at 790 days' follow up.

CONCLUSION:

This rare case increased our awareness of PTLD in the oral cavity of patients following solid organ transplantation and immunosuppressive therapy.

PMID:
18093326
[PubMed]
PMCID:
PMC2231341
Free PMC Article

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