Clin Pharmacol Ther. 2008 Apr;83(4):619-21. Epub 2007 Dec 19.

Monoamine oxidase inhibition for tobacco pharmacotherapy.

Source

Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. tony.george@utoronto.ca

Abstract

Tobacco addiction is the most significant preventable cause of morbidity and mortality in the Western world, with >430,000 deaths annually from tobacco-related diseases being reported in the United States. Although effective treatments are available for cessation of smoking (e.g., nicotine replacement therapies, sustained-release bupropion and varenicline), they do not work for all smokers. Therefore the development of more effective medications for treating tobacco dependence, based on novel mechanisms, is a high priority. This article reviews the links between smoking and monoamine oxidase (MAO) inhibition, which could lead to the development of novel pharmacotherapies to treat tobacco dependence.

PMID:: 18091758; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Education

New England Research Institutes Inc.

Medical

Supplemental Content

Save items

Related citations in PubMed

Review A review of the efficacy of smoking-cessation pharmacotherapies in nonwhite populations. [Clin Ther. 2008]
Review A review of the efficacy of smoking-cessation pharmacotherapies in nonwhite populations.
Robles GI, Singh-Franco D, Ghin HL. Clin Ther. 2008 May; 30(5):800-12.
Review Current pharmacological treatments for nicotine dependence. [Trends Pharmacol Sci. 2004]
Review Current pharmacological treatments for nicotine dependence.
George TP, O'Malley SS. Trends Pharmacol Sci. 2004 Jan; 25(1):42-8.
Review Monoamine oxidase and tobacco dependence. [Neurotoxicology. 2007]
Review Monoamine oxidase and tobacco dependence.
Lewis A, Miller JH, Lea RA. Neurotoxicology. 2007 Jan; 28(1):182-95. Epub 2006 Jul 21.
Review Current and emerging pharmacotherapies for treating tobacco dependence. [Expert Opin Emerg Drugs. 2006]
Review Current and emerging pharmacotherapies for treating tobacco dependence.
Schnoll RA, Lerman C. Expert Opin Emerg Drugs. 2006 Sep; 11(3):429-44.
Review Smoking cessation pharmacotherapy--nicotine and non-nicotine preparations. [Prev Cardiol. 2007]
Review Smoking cessation pharmacotherapy--nicotine and non-nicotine preparations.
Frishman WH. Prev Cardiol. 2007 Spring; 10(2 Suppl 1):10-22.

See reviews... See all...

Cited by 4 PubMed Central articles

Review Targeting nicotine addiction: the possibility of a therapeutic vaccine. [Drug Des Devel Ther. 2011]
Review Targeting nicotine addiction: the possibility of a therapeutic vaccine.
Escobar-Chávez JJ, Domínguez-Delgado CL, Rodríguez-Cruz IM. Drug Des Devel Ther. 2011; 5:211-24. Epub 2011 Apr 18.
Markov model of smoking cessation. [Proc Natl Acad Sci U S A. 2011]
Markov model of smoking cessation.
Killeen PR. Proc Natl Acad Sci U S A. 2011 Sep 13; 108 Suppl 3:15549-56. Epub 2011 Apr 20.
Changes in smoking expectancies in abstinent, reducing, and non-abstinent participants during a pharmacological trial for smoking cessation. [Nicotine Tob Res. 2010]
Changes in smoking expectancies in abstinent, reducing, and non-abstinent participants during a pharmacological trial for smoking cessation.
Weinberger AH, McKee SA, George TP. Nicotine Tob Res. 2010 Sep; 12(9):937-43. Epub 2010 Jul 19.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Monoamine oxidase inhibition for tobacco pharmacotherapy.
Monoamine oxidase inhibition for tobacco pharmacotherapy.
Clin Pharmacol Ther. 2008 Apr ;83(4):619-21. Epub 2007 Dec 19 .

PubMed
Deriving structure from evolution: metazoan segmentation.
Deriving structure from evolution: metazoan segmentation.
Mol Syst Biol. 2007 ;3:154. Epub 2007 Dec 18 .

PubMed
Modeling the regulatory network of histone acetylation in Saccharomyces cerevisi...
Modeling the regulatory network of histone acetylation in Saccharomyces cerevisiae.
Mol Syst Biol. 2007 ;3:153. Epub 2007 Dec 18 .

PubMed
[Updated treatment of peritoneal carcinomas: a review].
[Updated treatment of peritoneal carcinomas: a review].
Minerva Chir. 2007 Dec ;62(6):459-76.

PubMed
Circulating angiopoietin 2 correlates with mortality in a surgical population wi...
Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome.
Shock. 2008 Jun ;29(6):656-61.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: