Appl Immunohistochem Mol Morphol. 2008 Jan;16(1):54-8.

Her-2/neu expression in salivary duct carcinoma: an immunohistochemical and chromogenic in situ hybridization study.

Johnson CJ, Barry MB, Vasef MA, Deyoung BR.

Source

Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Abstract

Salivary duct carcinoma (SDC) shares significant morphologic and immunophenotypic overlap with ductal carcinoma of the breast, including HER-2/neu expression. Previous studies have detected HER-2/neu at the protein level in SDCs; however, no study, to date, has assayed whether this expression is related to gene amplification detected by chromogenic in situ hybridization (CISH). Formalin-fixed, paraffin-embedded tissue sections from 12 previously diagnosed SDCs were evaluated by immunohistochemistry (IHC) and CISH for HER-2/neu status. Result concordance was seen in all 12 cases. A total of 4 SDCs were positive by IHC; all 4 cases showed amplification with CISH. The remaining 8 cases were negative by IHC and showed no gene amplification with CISH. SDCs in this study show HER-2/neu overexpression on both the protein and gene levels in approximately 30% of cases. These findings suggest a role may exist for Herceptin (trastuzumab) based therapy in some SDC patients.

PMID:: 18091319; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

Receptor, erbB-2

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Supplemental Content

Save items

Related citations in PubMed

Chromogenic in situ hybridization (CISH): a novel alternative in screening archival breast cancer tissue samples for HER-2/neu status. [Breast Cancer Res. 2004]
Chromogenic in situ hybridization (CISH): a novel alternative in screening archival breast cancer tissue samples for HER-2/neu status.
Madrid MA, Lo RW. Breast Cancer Res. 2004; 6(5):R593-600. Epub 2004 Jul 29.
Analysis of HER-2/neu amplification in endometrial carcinoma by chromogenic in situ hybridization. Correlation with fluorescence in situ hybridization, HER-2/neu, p53 and Ki-67 protein expression, and outcome. [Mod Pathol. 2004]
Analysis of HER-2/neu amplification in endometrial carcinoma by chromogenic in situ hybridization. Correlation with fluorescence in situ hybridization, HER-2/neu, p53 and Ki-67 protein expression, and outcome.
Peiró G, Mayr D, Hillemanns P, Löhrs U, Diebold J. Mod Pathol. 2004 Mar; 17(3):227-87.
[Comparision of HER2/neu oncogene detected by chromogenic in-situ hybridization and immunohistochemistry in breast cancer]. [Zhonghua Bing Li Xue Za Zhi. 2...]
[Comparision of HER2/neu oncogene detected by chromogenic in-situ hybridization and immunohistochemistry in breast cancer].
Zhang GH, Shi DR, Liang XM, Hou JH, Kang SY, Zhu WD, Li XB, Shao Y, Chen LR, Zhou Y. Zhonghua Bing Li Xue Za Zhi. 2006 Oct; 35(10):580-3.
Review Predicting the efficacy of trastuzumab-based therapy in breast cancer: current standards and future strategies. [Biochim Biophys Acta. 2008]
Review Predicting the efficacy of trastuzumab-based therapy in breast cancer: current standards and future strategies.
Singer CF, Köstler WJ, Hudelist G. Biochim Biophys Acta. 2008 Dec; 1786(2):105-13. Epub 2008 Mar 4.
Review Hidden HER-2/neu-positive breast cancer: how to maximize detection. [IDrugs. 2009]
Review Hidden HER-2/neu-positive breast cancer: how to maximize detection.
Carney WP. IDrugs. 2009 Apr; 12(4):238-42.

See reviews... See all...

Cited by 1 PubMed Central article

Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy. [BMC Cancer. 2010]
Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy.
Liu G, Zheng H, Zhang Z, Wu Z, Xiong H, Li J, Song L. BMC Cancer. 2010 Sep 16; 10:495. Epub 2010 Sep 16.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Her-2/neu expression in salivary duct carcinoma: an immunohistochemical and chro...
Her-2/neu expression in salivary duct carcinoma: an immunohistochemical and chromogenic in situ hybridization study.
Appl Immunohistochem Mol Morphol. 2008 Jan ;16(1):54-8.

PubMed
The clinical relevance of asbestos-induced pleural fibrosis.
The clinical relevance of asbestos-induced pleural fibrosis.
Ann N Y Acad Sci. 1991 Dec 31 ;643:169-77.

PubMed
A telephone-only motivational intervention to increase physical activity in rura...
A telephone-only motivational intervention to increase physical activity in rural adults: a randomized controlled trial.
Nurs Res. 2008 Jan-Feb ;57(1):24-32.

PubMed
The National Study on Costs and Outcomes of Trauma.
The National Study on Costs and Outcomes of Trauma.
J Trauma. 2007 Dec ;63(6 Suppl):S54-67; discussion S81-6.

PubMed
Population-based register of stroke: manual of operations.
Population-based register of stroke: manual of operations.
Eur J Cardiovasc Prev Rehabil. 2007 Dec ;14 Suppl 3:S23-41.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: