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    Neuroreport. 2007 Nov 19;18(17):1761-4.

    Association between SORL1 and Alzheimer's disease in a genome-wide study.

    Meng Y, Lee JH, Cheng R, St George-Hyslop P, Mayeux R, Farrer LA.

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    Department of Medicine (Genetics Program), Boston University School of Medicine, Boston, Massachusetts 02118, USA.

    Abstract

    Several studies have reported an association of Alzheimer's disease (AD) with polymorphic markers in SORL1. Data from a recently published genome-wide association study in AD have been made publicly available. We tested the association of AD with SORL1 in this dataset (Translational Genomics Research Institute; TGEN), which included 31 SORL1 single nucleotide polymorphisms (SNPs), eight of which overlapped the original study. Six SNPs, near the 3' region of SORL1 containing SNPs which were strongly associated with AD in previous studies, showed significant association in the TGEN dataset. These results provide an independent replication of the association between AD and SORL1.

    PMID:
    18090307
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2631643
    Free PMC Article

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