Skin Therapy Lett. 2007 Nov;12(9):4-7.

Treatment of hand and foot psoriasis with emphasis on efalizumab.

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Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA.

Abstract

Hand and foot psoriasis is a chronic and debilitating disease that manifests as plaque-type or pustular-type lesions. Although the palms and soles represent only 2% of the total body surface area, psoriasis of these regions may lead to physical dysfunctions that can greatly impair dexterity, mobility, and the quality of life of affected individuals. Deregulation of T-lymphocyte-mediated immune response is important in the pathophysiology of psoriasis. Efalizumab (Raptiva, Genentech) is an anti-CD11a monoclonal antibody that disrupts the interaction between T cells and antigen-presenting cells, thereby inhibiting various T-cell-mediated immune processes that include activation and trafficking. Recent evidence indicates that efalizumab may be beneficial for patients with hand and foot psoriasis.

PMID:: 18087658; [PubMed - indexed for MEDLINE]

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