Format

Send to:

Choose Destination
See comment in PubMed Commons below
Beijing Da Xue Xue Bao. 2007 Dec 18;39(6):653-6.

[Effect of Ganoderma lucidum polysaccharides peptide on invasion of human lung carcinoma cells in vitro].

[Article in Chinese]

Author information

  • 1Department of Pharmacology, Peking University School of Basic Medical Sciences, Beijing 100083, China.

Abstract

OBJECTIVE:

To find out the effects of Ganoderma lucidum polysaccharides peptide (Gl-PP) on the invasion of the human lung carcinoma cell (PG cell).

METHODS:

PG cells were pretreated with different concentration Gl-PP in vitro, using cell proliferation assay, cell migration assay, adhesion assay, zymography and RT-PCR, then the effects of Gl-PP on proliferation, motility, adhesion and MMP-9 activity and mRNA expression of PG cells were investigated in vitro.

RESULTS:

Gl-PP did not directly inhibit PG cell proliferation in vitro. However, pretreated with Gl-PP, PG cells motility was inhibited significantly. PG cells adhesion was also inhibited. The activity of MMP-9 was inhibited in a dose-dependent manner, and the inhibited ratio was 41.53% at a dose of 100 mg/L Gl-PP. The mRNA expression of MMP-9 of pretreated PG cells was inhibited.

CONCLUSION:

Gl-PP could suppress invasion of human lung carcinoma cells in vitro.

PMID:
18087562
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Journal of Peking University (Health Sciences)
    Loading ...
    Write to the Help Desk