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    Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20793-8. Epub 2007 Dec 17.

    SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells.

    Kim JH, Lee JM, Nam HJ, Choi HJ, Yang JW, Lee JS, Kim MH, Kim SI, Chung CH, Kim KI, Baek SH.

    Source

    Department of Biological Sciences, Research Center for Functional Cellulomics and School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, South Korea.

    Abstract

    Posttranslational modification by small ubiquitin-like modifier (SUMO) controls diverse cellular functions of transcription factors and coregulators and participates in various cellular processes including signal transduction and transcriptional regulation. Here, we report that pontin, a component of chromatin-remodeling complexes, is SUMO-modified, and that SUMOylation of pontin is an active control mechanism for the transcriptional regulation of pontin on androgen-receptor target genes in prostate cancer cells. Biochemical purification of pontin-containing complexes revealed the presence of the Ubc9 SUMO-conjugating enzyme that underlies its function as an activator. Intriguingly, 5alpha-dihydroxytestosterone treatments significantly increased the SUMOylation of pontin, and SUMOylated pontin showed further activation of a subset of nuclear receptor-dependent transcription and led to an increase in proliferation and growth of prostate cancer cells. These data clearly define a functional model and provide a link between SUMO modification and prostate cancer progression.

    PMID:
    18087039
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2410081
    Free PMC Article

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