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Antimicrob Agents Chemother. 2008 Mar;52(3):1179-81. Epub 2007 Dec 17.

Systemic pharmacokinetics of rifaximin in volunteers with shigellosis.

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  • 1Center for Immunization Research, Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. david.taylor@vaxinnate.com


Rifaximin is an oral antibiotic indicated for treatment of traveler's diarrhea. Rifaximin pharmacokinetics were evaluated in individuals challenged with Shigella flexneri. Peak plasma rifaximin concentrations were low after nine consecutive doses, and no accumulation was observed. Rifaximin serum levels were minimal and similar to those previously reported in studies of healthy volunteers.

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