Abstract
When tested against nine strains of pneumococci and six of Haemophilus influenzae of various resistotypes, faropenem failed to select for resistant mutants after 50 days of consecutive subculture in subinhibitory concentrations. Faropenem also yielded low rates of spontaneous mutations against all organisms of both species. By comparison, resistant clones were obtained with macrolides, ketolides, and quinolones.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Drug Resistance, Bacterial / genetics*
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Haemophilus influenzae / drug effects*
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Haemophilus influenzae / genetics
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Haemophilus influenzae / growth & development
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Humans
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Ketolides / pharmacology
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Macrolides / pharmacology
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Mutation*
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Quinolones / pharmacology
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Selection, Genetic*
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Serial Passage
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Streptococcus pneumoniae / drug effects*
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Streptococcus pneumoniae / genetics
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Streptococcus pneumoniae / growth & development
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beta-Lactams / pharmacology*
Substances
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Anti-Bacterial Agents
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Ketolides
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Macrolides
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Quinolones
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beta-Lactams
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fropenem