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Subcell Biochem. 2007;44:115-41.

The peroxiredoxin repair proteins.

Author information

  • 1Center for Structural Biology, Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

Abstract

Sulfiredoxin and sestrin are cysteine sulfinic acid reductases that selectively reduce or repair the hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. As such these enzymes play key roles in the modulation of peroxide-mediated cell signaling and cellular defense mechanisms. The unique structure of sulfiredoxin facilitates access to the peroxiredoxin active site and novel sulfur chemistry.

PMID:
18084892
[PubMed - indexed for MEDLINE]
PMCID:
PMC2391273
Free PMC Article

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