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Mod Rheumatol. 2007;17(6):511-3. Epub 2007 Dec 20.

Gynecomastia associated with low-dose methotrexate therapy for rheumatoid arthritis.

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  • 1Department of Orthopaedic Surgery, Chiba-Tokushukai Hospital, Funabashi, Japan.


A 68-year-old man with a 3-year history of rheumatoid arthritis (RA) developed gynecomastia 3 months after beginning oral low-dose methotrexate (MTX) therapy. Four months after MTX therapy was discontinued, the gynecomastia symptoms improved. Only eight cases of gynecomastia resulting from low-dose MTX administration have been reported worldwide, and no cases have previously been reported in Japan. Although it occurs infrequently, gynecomastia resulting from low-dose MTX therapy should be considered in male patients with RA.

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