Warning: The NCBI web site requires JavaScript to function. more...

My NCBI Sign In

Result Filters

Rev Diabet Stud. 2007 Fall;4(3):185-94. Epub 2007 Nov 10.

Bromocriptine-induced hyperglycemia in nonobese diabetic mice: kinetics and mechanisms of action.

Durant S, Coulaud J, Homo-Delarche F.

Source

INSERM U530, Centre Universitaire-UFR biomedicale, 45, rue des Saints-Peres, 75006 Paris, France.

Abstract

The effects of bromocriptine (10 mg/kg), known to inhibit prolactin secretion and lower autoimmune processes, were studied on glucose homeostasis in non-fasted non-obese diabetic mice, a spontaneous model of type 1 diabetes. Hyperglycemia was observed 120 and 240 min after i.p. but not s.c. injection. Bromocriptine administration i.p. led to rapid and marked hyperglycemia characterized by sexual dimorphism with males having higher glycemia than females. Bromocriptine induced a rapid but transient decrease in insulinemia in males only and biphasic increases in glucagon levels and a sustained stimulatory effect on circulating corticosterone in both sexes. Bromocriptine-induced hyperglycemia involved D2-dopaminergic receptors, as demonstrated by the inhibitory effect of the D2-dopamine antagonist, metoclopramide (10 mg/kg). Simultaneous injection of bromocriptine and metoclopramide also blocked the rise in blood corticosterone. In conclusion, by inducing hyperglycemia, i.p. bromocriptine administration to prediabetic autoimmune mice may counteract its beneficial anti-immunostimulatory effects.

PMID:: 18084676; [PubMed - in process]
PMCID:: PMC2174061

Free PMC Article

Images from this publication.See all images (6) Free text

LinkOut - more resources

Full Text Sources

Supplemental Content

Icon for Society for Biomedical Diabetes Research

Icon for PubMed Central

Save items

loading

Related citations in PubMed

Attempts to pharmacologically modulate prolactin levels and type 1 autoimmune diabetes in the non-obese diabetic (NOD) mouse. [J Autoimmun. 1995]
Attempts to pharmacologically modulate prolactin levels and type 1 autoimmune diabetes in the non-obese diabetic (NOD) mouse.
Durant S, Alves V, Coulaud J, El Hasnaoui A, Dardenne M, Homo-Delarche F. J Autoimmun. 1995 Dec; 8(6):875-85.
Dopaminergic inhibition of metoclopramide-induced aldosterone secretion in man. Dissociation of responses to dopamine and bromocriptine. [J Clin Invest. 1980]
Dopaminergic inhibition of metoclopramide-induced aldosterone secretion in man. Dissociation of responses to dopamine and bromocriptine.
Carey RM, Thorner MO, Ortt EM. J Clin Invest. 1980 Jul; 66(1):10-8.
Glucose homeostasis in the nonobese diabetic mouse at the prediabetic stage. [Endocrinology. 1998]
Glucose homeostasis in the nonobese diabetic mouse at the prediabetic stage.
Amrani A, Durant S, Throsby M, Coulaud J, Dardenne M, Homo-Delarche F. Endocrinology. 1998 Mar; 139(3):1115-24.
Review Inhibition of glucagon secretion. [Adv Pharmacol. 2005]
Review Inhibition of glucagon secretion.
Young A. Adv Pharmacol. 2005; 52:151-71.
Review Diagnosis and drug therapy of prolactinoma. [Drugs. 1996]
Review Diagnosis and drug therapy of prolactinoma.
Ciccarelli E, Camanni F. Drugs. 1996 Jun; 51(6):954-65.

See reviews... See all...

Cited by 3 PubMed Central articles

Pharmacological modulation of dopamine receptor D2-mediated transmission alters the metabolic phenotype of diet induced obese and diet resistant C57Bl6 mice. [Exp Diabetes Res. 2011]
Pharmacological modulation of dopamine receptor D2-mediated transmission alters the metabolic phenotype of diet induced obese and diet resistant C57Bl6 mice.
de Leeuw van Weenen JE, Parlevliet ET, Schröder-van der Elst JP, van den Berg SA, Willems van Dijk K, Romijn JA, Pijl H. Exp Diabetes Res. 2011; 2011:928523. Epub 2011 Apr 6.
Leptin increases striatal dopamine D2 receptor binding in leptin-deficient obese (ob/ob) mice. [Synapse. 2010]
Leptin increases striatal dopamine D2 receptor binding in leptin-deficient obese (ob/ob) mice.
Pfaffly J, Michaelides M, Wang GJ, Pessin JE, Volkow ND, Thanos PK. Synapse. 2010 Jul; 64(7):503-10.
Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity. [Neuroendocrinology. 2009]
Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity.
Davis LM, Michaelides M, Cheskin LJ, Moran TH, Aja S, Watkins PA, Pei Z, Contoreggi C, McCullough K, Hope B, et al. Neuroendocrinology. 2009; 89(2):152-62. Epub 2008 Nov 4.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Bromocriptine-induced hyperglycemia in nonobese diabetic mice: kinetics and mech...
Bromocriptine-induced hyperglycemia in nonobese diabetic mice: kinetics and mechanisms of action.
Rev Diabet Stud. 2007 Fall ;4(3):185-94. Epub 2007 Nov 10 .

PubMed
Zinc sulphate following the administration of iodine-131 on the regulation of th...
Zinc sulphate following the administration of iodine-131 on the regulation of thyroid function, in rats.
Hell J Nucl Med. 2007 Sep-Dec ;10(3):167-71.

PubMed
[The complex plague--reconsiderations of an epidemic from the past].
[The complex plague--reconsiderations of an epidemic from the past].
Tidsskr Nor Laegeforen. 2007 Dec 13 ;127(24):3272-5.

PubMed
Array painting reveals a high frequency of balanced translocations in breast can...
Array painting reveals a high frequency of balanced translocations in breast cancer cell lines that break in cancer-relevant genes.
Oncogene. 2008 May 22 ;27(23):3345-59. Epub 2007 Dec 17 .

PubMed
Celecoxib modulates adhesion of HT29 colon cancer cells to vascular endothelial ...
Celecoxib modulates adhesion of HT29 colon cancer cells to vascular endothelial cells by inhibiting ICAM-1 and VCAM-1 expression.
Br J Pharmacol. 2008 Mar ;153(6):1153-61. Epub 2007 Dec 17 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

You are here: NCBI > Literature > PubMed

Write to the Help Desk