-
Clinical and serologic responses of volunteers infected with phlebotomus fever virus (Sicilian type).
Twenty volunteers were inoculated with various doses of human serum containing Phlebotomus fever virus (Sicilian type) to determine their clinical and serologic responses as well as the human infectious dose50 of the virus. All infected subjects developed fever which varied in duration from 6 to 74 hours. The most common symptoms during sandfly fever were headache, anorexia, myalgia, photophobia, low back and retro-orbital pain. Infected individuals developed a marked leukopenia characterized by an initial lymphopenia followed by protracted neutropenia. Little complement fixing antibody was detected in convalescent sera but most subjects developed significant rises in hemagglutination inhibiting antibodies. All infected subjects developed specific neutralizing antibodies with titers ranging from 1:40 to 1:2,560. Of the three serologic tests performed, the plaque reduction neutralization method appears to be the most sensitive test for detecting antibodies to Phlebotomus fever viruses.
PMID: 180844 [PubMed - indexed for MEDLINE]
-
Cited by 6 PubMed Central articles
-
The S segment of Punta Toro virus (Bunyaviridae, Phlebovirus) is a major determinant of lethality in the Syrian hamster and codes for a type I interferon antagonist.
Perrone LA, Narayanan K, Worthy M, Peters CJ.
J Virol. 2007 Jan; 81(2):884-92. Epub 2006 Oct 18.
[J Virol. 2007]
-
B-cell and T-cell immune responses to experimental Helicobacter pylori infection in humans.
Nurgalieva ZZ, Conner ME, Opekun AR, Zheng CQ, Elliott SN, Ernst PB, Osato M, Estes MK, Graham DY.
Infect Immun. 2005 May; 73(5):2999-3006.
[Infect Immun. 2005]
-
Challenge model for Helicobacter pylori infection in human volunteers.
Graham DY, Opekun AR, Osato MS, El-Zimaity HM, Lee CK, Yamaoka Y, Qureshi WA, Cadoz M, Monath TP.
Gut. 2004 Sep; 53(9):1235-43.
[Gut. 2004]
- » See all...