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Nat Genet. 2008 Jan;40(1):29-31. Epub 2007 Dec 16.

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.

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  • 1Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.

Abstract

We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.

PMID:
18084291
[PubMed - indexed for MEDLINE]
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