Kidney Int. 2008 Jan;73(1):7-8.

Innate immunity as a driving force in renal disease.

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Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. e.de_heer@lumc.nl

Abstract

Mrug et al. propose that innate immunity is a hallmark of progressive polycystic kidney disease (PKD). We propose that innate immunity is a driving force in the progression of many renal diseases. Renal epithelial cells are capable of expressing a large variety of proinflammatory genes resulting in the production of cytokines, chemokines, cell-adhesion molecules, and complement components. We suggest that future therapeutic interventions should be directed toward control of innate immunity in renal disease.

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Kidney Int. 2008 Jan;73(1):63-76.

PMID:: 18084263; [PubMed - indexed for MEDLINE]

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