My NCBISign In

Display Settings:

Format

Send to:

Choose Destination
    Ann N Y Acad Sci. 2007 Nov;1116:499-506.

    Evolution, aging, and osteoporosis.

    Tung S, Iqbal J.

    Source

    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.

    Abstract

    Aging is a process whereby organisms lose to the capacity to effectively handle life's stresses. Associated with aging are pathophysiological processes, such as decreases in bone mass, which in the extreme form lead to significant morbidity. Evolutionary theory suggests that these pathophysiological processes are permitted to occur because an organism need only preserve its body against stress only for the amount of time needed for effective reproduction. In this review, an understanding of osteoporosis and bone loss is discussed within the context of aging theory. Specific topics covered include: (1) bone loss as an antagonistically pleiotropic physiological process, (2) age-associated stress accumulation and its negative impact on bone turnover, and (3) the mechanisms whereby gonadal failure, increases in inflammatory cytokines, and cellular bone marrow changes lead to bone loss. This review concludes by examining purported hypotheses in the context of Werner's syndrome, a disease characterized by premature aging. We suggest that future osteoporosis therapy will likely focus on prevention of aging in general as a means to prevent the development of osteoporosis.

    PMID:
    18083942
    [PubMed - indexed for MEDLINE]

    Publication Types, MeSH Terms

    Publication Types

    MeSH Terms

    LinkOut - more resources

    Full Text Sources

    Medical

      Supplemental Content

      Icon for Blackwell Publishing

      Save items

      loading

      Related citations in PubMed

      See reviews... See all...

      Recent activity

      Clear Turn Off Turn On
      • Evolution, aging, and osteoporosis.
        Evolution, aging, and osteoporosis.
        Ann N Y Acad Sci. 2007 Nov ;1116:499-506.
        PubMed
      • Sodium channels and cystic fibrosis.
        Sodium channels and cystic fibrosis.
        Chest. 2007 Nov ;132(5):1631-6.
        PubMed
      • 17998363[uid] (1)
        PubMed
      • Scientific knowledge gaps and clinical research priorities for cardiopulmonary r...
        Scientific knowledge gaps and clinical research priorities for cardiopulmonary resuscitation and emergency cardiovascular care identified during the 2005 International Consensus Conference on ECC [corrected] and CPR science with treatment recommendations: a consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian Resuscitation Council, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Southern Africa, and the New Zealand Resuscitation Council); the American Heart Association Emergency Cardiovascular Care Committee; the Stroke Council; and the Cardiovascular Nursing Council.".
        Circulation. 2007 Nov 20 ;116(21):2501-12. Epub 2007 Nov 9 .
        PubMed
      • Assessment of pancreatic function in screened infants with cystic fibrosis.
        Assessment of pancreatic function in screened infants with cystic fibrosis.
        Pediatr Pulmonol Suppl. 1991 ;7:69-71.
        PubMed

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      You are here: NCBI > Literature > PubMed
      Write to the Help Desk