Cell. 2007 Dec 14;131(6):1047-58.

Calcium signaling.

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Aldo R. Castañeda Professor of Cardiovascular Research, Professor of Neurobiology, Harvard Medical School, Howard Hughes Medical Institute, Enders 1309, Children's Hospital Boston, Boston, MA 02115, USA. dclapham@enders.tch.harvard.edu

Abstract

Calcium ions (Ca(2+)) impact nearly every aspect of cellular life. This review examines the principles of Ca(2+) signaling, from changes in protein conformations driven by Ca(2+) to the mechanisms that control Ca(2+) levels in the cytoplasm and organelles. Also discussed is the highly localized nature of Ca(2+)-mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription.

PMID:: 18083096; [PubMed - indexed for MEDLINE]

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