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Pharmacol Ther. 2008 Feb;117(2):232-43. Epub 2007 Dec 20.

Muscarinic acetylcholine receptors as CNS drug targets.

Author information

  • 1Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Avenue, Harlow, Essex, CM19 5AW, UK. christopher.j.langmead@gsk.com <christopher.j.langmead@gsk.com>

Abstract

Muscarinic acetylcholine receptors (mAChRs) are widely expressed in the CNS where they control a variety of neuronal functions. Due to their roles in a number of CNS processes, mAChRs have long been a target of the drug discovery industry; however, the only mAChR ligands approved for use in the clinic are non-selective antagonists for the treatment of Parkinson's disease. This article briefly reviews recent progress made in mAChR drug discovery for Alzheimer's disease (AD), schizophrenia and Parkinson's disease, with particular emphasis on novel target validation, as well as highlighting novel indications such as drug addiction.

PMID:
18082893
[PubMed - indexed for MEDLINE]
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