Science. 2007 Dec 14;318(5857):1722; author reply 1722.

Comment on "Tumor growth need not be driven by rare cancer stem cells".

Kennedy JA, Barabé F, Poeppl AG, Wang JC, Dick JE.

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Division of Cell and Molecular Biology, University Health Network, Toronto, Canada.

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Kelly et al. (Brevia, 20 July 2007, p. 337) questioned xenotransplant experiments supporting the cancer stem cell (CSC) hypothesis because they found a high frequency of leukemia-initiating cells (L-IC) in some transgenic mouse models. However, the CSC hypothesis depends on prospective purification of cells with tumor-initiating capacity, irrespective of frequency. Moreover, we found similar L-IC frequencies in genetically comparable leukemias using syngeneic or xenogeneic models.

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Science. 2007 Jul 20;317(5836):337.

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