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Clin Chem Lab Med. 2008;46(2):212-4.

Changes in serum fetuin-A and inflammatory markers levels in end-stage renal disease (ESRD): effect of a single session haemodialysis.

Author information

  • 1Clinical Biochemistry, Faculty of Medicine, University of Palermo, Palermo, Italy. marcello.ciaccio@unipa.it

Abstract

BACKGROUND:

The aim of the present study was to evaluate the effect of a single haemodialysis (HD) session on serum fetuin-A levels, considered a negative acute phase response marker; moreover, we evaluated the behaviour of fibrinogen and high sensitivity C-reactive protein (hsCRP) as acute phase response and chronic/subclinical inflammation markers, respectively, after a single HD session.

METHODS:

Serum fetuin-A, albumin, hsCRP and fibrinogen were measured in 72 patients before and after a single HD session.

RESULTS:

After a single HD session, we observed a significant increase in fibrinogen levels, while fetuin-A levels decreased (p<0.05). Also, hsCRP levels were significantly increased.

CONCLUSIONS:

The significant decrease of fetuin-A levels after a single HD session is consistent with the hypothesis of HD-induced inflammation; activated acute phase response and fetuin-A deficiency might account for increased cardiovascular risk and accelerated atherogenesis in dialysis patients.

PMID:
18076347
[PubMed - indexed for MEDLINE]
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