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    Cell Cycle. 2007 Dec 15;6(24):3145-7. Epub 2007 Oct 3.

    Multiple kinases and system robustness: a link between Cdc37 and genome integrity.

    Caplan AJ, Ma'ayan A, Willis IM.

    Abstract

    We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.

    PMID:
    18075309
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3045565
    Free PMC Article

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