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Nat Rev Mol Cell Biol. 2008 Jan;9(1):22-32.

Argonaute proteins: key players in RNA silencing.

Author information

  • 1Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK. g.hutvagner@dundee.ac.uk

Abstract

During the past decade, small non-coding RNAs have rapidly emerged as important contributors to gene regulation. To carry out their biological functions, these small RNAs require a unique class of proteins called Argonautes. The discovery and our comprehension of this highly conserved protein family is closely linked to the study of RNA-based gene silencing mechanisms. With their functional domains, Argonaute proteins can bind small non-coding RNAs and control protein synthesis, affect messenger RNA stability and even participate in the production of a new class of small RNAs, Piwi-interacting RNAs.

PMID:
18073770
[PubMed - indexed for MEDLINE]
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