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J Med Toxicol. 2007 Dec;3(4):152-6.

Antiemetic use in acetaminophen poisoning: how does the route of N-acetylcysteine administration affect utilization?

Author information

  • 1Department of Pharmacy, UMass Memorial Medical Center, MA, USA.

Abstract

INTRODUCTION:

We sought to compare antiemetic use after acetaminophen poisoning in patients treated with oral or intravenous (IV) N-acetylcysteine (NAC).

METHODS:

Our retrospective chart review identified 20 orally treated patients and 17 IV-treated patients. For both groups, we calculated the total number of antiemetic doses given, their associated cost, and also determined parameters that correlated with antiemetic use.

RESULTS:

IV-treated patients received fewer total antiemetic doses than those receiving oral NAC (1.1 0.2 vs. 2.8 0.7; P 0.04). Antiemetic cost correlated with doses received for both groups; however, because the regression lines differed (P 0.02), antiemetic therapy cost was less in IV-treated patients. In addition, serum acetaminophen concentration correlated with total antiemetic doses in oral NAC patients (P 0.002) but not with IV treatment patients (P 0.78).

CONCLUSIONS:

Intravenous NAC reduced antiemetic utilization, and it costs less than oral therapy. Furthermore, antiemetic use appeared to be determined by a combination of acetaminophen concentration and NAC administration route.

PMID:
18072168
[PubMed - indexed for MEDLINE]
PMCID:
PMC3550020
Free PMC Article
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