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Nat Rev Genet. 2008 Jan;9(1):49-61.

The multifaceted role of Notch in cardiac development and disease.

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  • 1Department of Cell and Developmental Biology and the Cardiovascular Institute, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.


Notch receptors and their cognate ligands transduce crucial signals between cells in various tissues, and have been conserved across millions of years of evolution. Mutations in Notch signalling components result in congenital heart defects in humans and mice, demonstrating an essential role for Notch in cardiovascular development. The results of recent experiments implicate this signalling pathway in many stages of heart development, and provide mechanistic insight into the vital functions of Notch in the aetiology of several common forms of paediatric and adult cardiac disease.

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