Send to

Choose Destination
See comment in PubMed Commons below
Am J Surg. 2008 Apr;195(4):457-62.

Comparison of clinical characteristics at diagnosis and during follow-up in 118 patients with Hurthle cell or follicular thyroid cancer.

Author information

  • 1Department of Surgery, University of California San Francisco, UCSF/Mt Zion Medical Center, 1600 Divisadero Street #C347, San Francisco, CA 94143-1674, USA.



Hurthle cell cancer (HCC) is considered by some to be a variant of follicular cancer (FC), but many think it is a distinct histologic tumor with a more aggressive behavior.


The influence of age at diagnosis, tumor stage, gender, and extent of operation on disease-free interval and cause-specific mortality at 5 and 10 years after initial thyroidectomy was analyzed.


The 10-year disease-free interval was 75% for FC and 40.5% for HCC (P = .08). The 10-year cause-specific mortality was 20% for FC patients and 51% for HCC (P = .2). The risk factors for HCC progression and survival were extrathyroidal invasion, presence of metastases at diagnosis, male gender, and extent of thyroidectomy, whereas for FC, the only significant risk factors were extrathyroidal invasion and presence of metastases at diagnosis.


Patients with HCC have more aggressive tumors than patients with FC. Our data suggest that FC and HCC should be classified as distinct tumors.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk