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BMC Physiol. 2007 Dec 10;7:13.

An extensive phenotypic characterization of the hTNFalpha transgenic mice.

Author information

  • 1Caliper Discovery Alliances & Services (Xenogen Biosciences), 5 Cedar Brook Drive, Cranbury, NJ 08512, USA. Michael.Hayward@CaliperLS.com

Abstract

BACKGROUND:

Tumor necrosis factor alpha (TNFalpha) is implicated in a wide variety of pathological and physiological processes, including chronic inflammatory conditions, coronary artery disease, diabetes, obesity, and cachexia. Transgenic mice expressing human TNFalpha (hTNFalpha) have previously been described as a model for progressive rheumatoid arthritis. In this report, we describe extensive characterization of an hTNFalpha transgenic mouse line.

RESULTS:

In addition to arthritis, these hTNFalpha transgenic mice demonstrated major alterations in body composition, metabolic rate, leptin levels, response to a high-fat diet, bone mineral density and content, impaired fertility and male sexual function. Many phenotypes displayed an earlier onset and a higher degree of severity in males, pointing towards a significant degree of sexual dimorphism in response to deregulated expression of TNFalpha.

CONCLUSION:

These results highlight the potential usefulness of this transgenic model as a resource for studying the progressive effects of constitutively expressed low levels of circulating TNFalpha, a condition mimicking that observed in a number of human pathological conditions.

PMID:
18070349
[PubMed - indexed for MEDLINE]
PMCID:
PMC2222242
Free PMC Article
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