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    Dev Dyn. 2008 Jan;237(1):209-15.

    The macroPARP genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues.

    Hakmé A, Huber A, Dollé P, Schreiber V.

    Source

    Université Strasbourg 1, Institut Gilbert Laustriat, CNRS - UMR 7175, Département Intégrité du Génome, ESBS, Bld Sébastien Brant, BP 10413, Illkirch Cedex, France.

    Abstract

    The macroPARPs Parp-9 and Parp-14 are macro domain containing poly(ADP-ribose) polymerases involved in transcriptional regulation in response to immunoregulatory cytokines. Their genes reside in the same locus (16B3), and the Parp-9 gene lies head-to-head and shares its promoter with the gene encoding its partner, Bbap. Here, we provide a detailed analysis of Parp-9, Parp-14, and Bbap expression during mouse development and adulthood. Parp-9 is developmentally regulated, and prominently expressed in the thymus and specific regions of the brain and gut. In adults, highest expression is maintained in the thymus and intestine. Parp-14 is more weakly expressed, mainly in the thymus during development and in adulthood. In addition, we show that Bbap is essentially coexpressed with Parp-9 during development and in adult mouse. However, the different levels of their transcripts detected in the developing brain and gut suggest that Bbap and Parp-9 display both common and independent tissue-specific regulations.

    PMID:
    18069692
    [PubMed - indexed for MEDLINE]
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