Best Pract Res Clin Rheumatol. 2007 Dec;21(6):1025-36.

Localized scleroderma and systemic sclerosis: is there a connection?

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Department of Dermatology, Stanford University Medical Center, Stanford, CA 94305, USA.

Abstract

Excess fibrosis of the skin is a clinical hallmark of both localized scleroderma and systemic sclerosis. Localized scleroderma is generally thought to be a skin-limited disease whereas systemic sclerosis can have a wide range of internal organ involvement. Recent data suggest that a subset of patients with juvenile localized scleroderma can go on to develop systemic involvement of their disease. This raises the question of what the connection is, if any, between localized scleroderma and systemic sclerosis.

PMID:: 18068859; [PubMed - indexed for MEDLINE]

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