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Cytokine Growth Factor Rev. 2008 Feb;19(1):33-40.

Type I interferon as a stimulus for cross-priming.

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  • 1INSERM U591 - Marie Curie Excellence Team, AVENIR Group, Faculté Necker, 156 rue de Vaugirard, 75015 Paris, France. lebon@necker.fr


Type I interferon (IFN-alpha/beta) is induced rapidly by infection and is well recognised for its crucial role in innate defence. However, it is evident that IFN-alpha/beta also serves as a signal for the generation of adaptive immune responses. In this review, we focus on the involvement of IFN-alpha/beta in the induction of CD8+ T cell responses by cross-priming.

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