Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1523-7.

Mass spectrometry based methods for analysis of nucleosides as antiviral drugs and potential tumor biomarkers.

Agrofoglio LA, Bezy V, Chaimbault P, Delépée R, Rhourri B, Morin P.

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Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, 45067 Orléans Cedex 2, France. luigi.agrofoglio@univ-orleans.fr

Abstract

The intracellular analysis of the phosphorylated metabolites of some anti-HIV nucleosides by liquid chromatography or capillary electrophoresis coupled with tandem mass spectrometry (LC-MS/MS or CE-MS/MS) has been realized on human peripheral blood mononuclear cells (PBMC), with limit of quantitation (LOQ) that allow them to be quantitated intracellularly. We described also the analysis of modified urinary nucleosides as potential tumor biomarkers.

PMID:: 18066819; [PubMed - indexed for MEDLINE]

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