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Can J Physiol Pharmacol. 2007 Dec;85(12):1215-25.

Adventures in drug disposition: pas seulement pâté de foie.

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  • 1Department of Pharmacology and Therapeutics, Faculty of Medicine, Centre on Aging, University of Manitoba, A220-753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada. sitar@cc.umanitoba.ca

Abstract

Interindividual variability in drug disposition and effect has served to confound the optimization of drug therapy. Over my career, I have focused on delineating mechanisms that contribute to this variability, with the goal of improving the benefit : risk ratio when drug therapy is chosen as an intervention strategy. In this manuscript, I present some of our experimental findings that I believe have contributed to an increased understanding of variability in drug disposition and efficacy.

PMID:
18066123
[PubMed - indexed for MEDLINE]
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