Send to:

Choose Destination
See comment in PubMed Commons below
Can J Physiol Pharmacol. 2007 Dec;85(12):1215-25.

Adventures in drug disposition: pas seulement pâté de foie.

Author information

  • 1Department of Pharmacology and Therapeutics, Faculty of Medicine, Centre on Aging, University of Manitoba, A220-753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada.


Interindividual variability in drug disposition and effect has served to confound the optimization of drug therapy. Over my career, I have focused on delineating mechanisms that contribute to this variability, with the goal of improving the benefit : risk ratio when drug therapy is chosen as an intervention strategy. In this manuscript, I present some of our experimental findings that I believe have contributed to an increased understanding of variability in drug disposition and efficacy.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Write to the Help Desk